Table 3.
Univariable and multivariable predictors of HCC recurrence (Time to recurrence).
| Predictor | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Recipient male sex (vs. female) | 3.018 | 0.392-23.213 | 0.289 | |||
| Recipient age (per year increase) | 0.977 | 0.918-1.040 | 0.463 | |||
| Recipient body mass index (per kg/m2 increase) | 0.944 | 0.842-1.058 | 0.320 | |||
| Recipient diabetes (yes vs. no) | 0.502 | 0.111-2.266 | 0.370 | |||
| Cirrhosis aetiology | 0.714 | 0.420-1.214 | 0.214 | |||
| Pre-LT Child-Pugh score (per category increase) | 0.784 | 0.367-1.674 | 0.529 | |||
| Pre-LT MELD score (per point increase) | 0.960 | 0.877-1.050 | 0.369 | |||
| Pre-LT HCC treatment (yes vs. no) | 4.226 | 0.549-32.501 | 0.166 | |||
| Pre-LT AFP level (per kIU/L increase) | 1.003 | 0.998-1.007 | 0.218 | |||
| Time spent on waitlist (per month increase) | 1.026 | 1.000-1.052 | 0.048 | 1.002 | 0.963-1.044 | 0.905 |
| Number of HCCs seen on explant (per number increase) | 1.299 | 1.056-1.598 | 0.013 | 0.923 | 0.568-1.499 | 0.746 |
| Size of largest HCC seen on explant (per mm increase) | 1.029 | 0.988-1.071 | 0.175 | |||
| HCC histological differentiation (per grade increase) | 0.755 | 0.265-2.150 | 0.599 | |||
| Macrotrabecular massive subtype (yes vs. no) | 4.103 | 1.342-12.544 | 0.013 | 2.696 | 0.684-10.628 | 0.156 |
| Presence of microvascular invasion (yes vs. no) | 3.605 | 1.211-10.729 | 0.021 | 1.670 | 0.453-6.156 | 0.441 |
| Presence of perineural invasion (yes vs. no) | 4.329 | 0.562-33.346 | 0.160 | |||
| Presence of VETC pattern (yes vs. no) | 1.741 | 0.386-7.853 | 0.471 | |||
| Highest VETC index per patient (per point increase)* | 1.015 | 0.999-1.032 | 0.072 | 0.997 | 0.974-1.022 | 0.835 |
| Total number of VETC-positive HCCs (per number increase)* | 1.405 | 1.146-1.723 | 0.001 | 1.411 | 1.153-1.726 | 0.001 |
| Sum of VETC indices across all HCCs per patient (per point increase)* | 1.005 | 1.001-1.008 | 0.007 | 0.999 | 0.992-1.007 | 0.880 |
| Average VETC index per HCC per patient (per point increase)* | 1.023 | 0.997-1.049 | 0.079 | 1.004 | 0.968-1.041 | 0.848 |
*entered into separate models to each other along with other significant predictors found on univariable analysis.
AFP, alpha-fetoprotein; CI, confidence interval; HCC, hepatocellular carcinoma; HR, hazard ratio; LT, liver transplantation; MELD, model for end-stage liver disease; VETC, vessels that encapsulate tumor clusters.
The bold values are the significant values (where P<0.05).