Table 4.
Univariable and multivariable predictors of HCC recurrence or mortality (Recurrence-free survival).
| Predictor | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Recipient male sex (vs. female) | 1.634 | 0.570-4.685 | 0.361 | |||
| Recipient age (per year increase) | 1.018 | 0.966-1.072 | 0.514 | |||
| Recipient body mass index (per kg/m2 increase) | 0.964 | 0.896-1.036 | 0.319 | |||
| Recipient diabetes (yes vs. no) | 0.483 | 0.168-1.392 | 0.178 | |||
| Cirrhosis aetiology | 0.901 | 0.704-1.153 | 0.407 | |||
| Pre-LT Child-Pugh score (per category increase) | 1.175 | 0.718-1.925 | 0.521 | |||
| Pre-LT MELD score (per point increase) | 1.015 | 0.966-1.066 | 0.555 | |||
| Pre-LT HCC treatment (yes vs. no) | 2.843 | 0.979-8.257 | 0.055 | 1.858 | 0.431-8.010 | 0.406 |
| Pre-LT AFP level (per kIU/L increase) | 1.002 | 0.999-1.005 | 0.158 | |||
| Time spent on waitlist (per month increase) | 1.020 | 1.002-1.039 | 0.028 | 1.017 | 0.999-1.037 | 0.069 |
| Number of HCCs seen on explant (per number increase) | 1.086 | 0.894-1.320 | 0.405 | |||
| Size of largest HCC seen on explant (per mm increase) | 1.006 | 0.977-1.035 | 0.708 | |||
| HCC histological differentiation (per grade increase) | 1.144 | 0.566-2.313 | 0.708 | |||
| Macrotrabecular massive subtype (yes vs. no) | 1.686 | 0.685-4.148 | 0.255 | |||
| Presence of microvascular invasion (yes vs. no) | 1.723 | 0.799-3.714 | 0.165 | |||
| Presence of perineural invasion (yes vs. no) | 1.839 | 0.250-13.530 | 0.549 | |||
| Presence of VETC pattern (yes vs. no)* | 2.799 | 0.847-9.251 | 0.091 | 3.601 | 0.850-15.251 | 0.082 |
| Highest VETC index per patient (per point increase) | 1.003 | 0.988-1.018 | 0.671 | |||
| Total number of VETC-positive HCCs (per number increase)* | 1.269 | 1.051-1.532 | 0.013 | 1.267 | 1.048-1.531 | 0.014 |
| Sum of VETC indices across all HCCs per patient (per point increase) | 1.003 | 0.999-1.007 | 0.110 | |||
| Average VETC index per HCC per patient (per point increase) | 1.009 | 0.986-1.033 | 0.449 | |||
*entered into separate models to each other along with other significant predictors found on univariable analysis.
AFP, alpha-fetoprotein; CI, confidence interval; HCC, hepatocellular carcinoma; HR, hazard ratio; LT, liver transplantation; MELD, model for end-stage liver disease; VETC, vessels that encapsulate tumor clusters.
The bold values are the significant values (where P<0.05).