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. 2022 Oct 26;12:959630. doi: 10.3389/fonc.2022.959630

Figure 2.

Figure 2

Expression of the direct miR-10b target, HOXD10, in patients with FMC. (A) qRT-PCR analysis of HOXD10 expression in primary tumors and lymph node metastases in spontaneous mammary carcinoma in cats. Data from cats 0, 1, 8, 9 and 7 are shown. HOXD10 expression was significantly higher in the primary tumors than in the metastases (n = 3, p < 0.01). Data are represented as mean ± s.d. (B) Representative staining for HOXD10, a direct miR-10b target, demonstrating strong signal in the primary tumor (left) and a lower signal in lymph node metastases (right). Scale bar = 100µm. (C) Representative ISH field of a primary breast tumor showing miR-10b expression at the invasive front (—) and detached invading cancer cells (arrow) migrating as a group (….) and individually. Scale bar = 100µm.