Table 2.

Incidence rates and IRRs for self-harm according to exposure to quetiapine.

Exposure		Total self-harm events	Total person-years	Incidence rate per year	Crude IRR	IRR adjusted for age	IRR adjusted for all time-varying confounders*
More than 12 months prior to quetiapine use	Unexposed	344	667.7	0.52	1	1	1
<12–8 months prior to quetiapine use		92	114.6	0.8	1.56 (1.22, 1.97)	1.23 (0.97, 1.57)	1.20 (0.94, 1.53)
<8–4 months prior to quetiapine use		118	141.4	0.03	1.62 (1.30, 2.00)	1.30 (1.04, 1.63)	1.26 (0.99, 1.60)
<4–3 months prior to quetiapine use	Pre-exposed	55	41.1	1.34	2.60 (1.92, 3.46)	2.08 (1.54, 2.80)	2.05 (1.51, 2.79)
<3–2 months prior to quetiapine use		60	46.1	1.3	2.52 (1.89, 3.33)	2.04 (1.53, 2.73)	2.03 (1.51, 2.74)
<2–1 months prior to quetiapine use		71	52.4	1.36	2.63 (2.01, 3.41)	2.15 (1.64, 2.83)	2.18 (1.64, 2.89)
<1–0 month prior to quetiapine use		134	64	2.09	4.06 (3.30, 4.98)	3.45 (2.76, 4.31)	3.59 (2.83, 4.55)
0–<1 month of quetiapine use		163	104.3	1.56	3.03 (2.50, 3.66)	2.07 (1.67, 2.58)	1.85 (1.46, 2.34)
1–<2 months after start of quetiapine use		166	101.9	1.63	3.16 (2.61, 3.82)	2.19 (1.76, 2.72)	1.96 (1.55, 2.48)
2–<3 months after start of quetiapine use		124	99	1.25	2.43 (1.96, 2.99)	1.71 (1.35, 2.16)	1.54 (1.19, 1.98)
3–<4 months after start of quetiapine use	Exposed	89	77.4	1.15	2.23 (1.75, 2.83)	1.52 (1.17, 1.98)	1.38 (1.04, 1.82)
4–<8 months after start of quetiapine use		266	233.4	1.14	2.21 (1.88, 2.60)	1.57 (1.28, 1.92)	1.43 (1.14, 1.79)
8–<12 months after start of quetiapine use		165	162.7	1.01	1.96 (1.62, 2.38)	1.48 (1.18, 1.86)	1.37 (1.06, 1.75)
>12 months after start of quetiapine use		495	697.9	0.71	1.38 (1.20, 1.58)	1.26 (1.03, 1.55)	1.17 (0.92, 1.48)

IRR: incidence rate ratio.

^*Age, calendar year, psychotropic medications.