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Microtubule perturbants inhibit TDH-induced morphological changes in IEC-6 cells as viewed by fluorescence detection of F-actin. Cells were treated with cytochalasin D (a and b), jasplakinolide (c and d), vinblastine (e and f), or taxol (g and h). Cells in panel b, d, f, and h were subsequently exposed to TDH for 18 h. Note that only the microtubule-perturbing drugs are able to inhibit the formation of filopodia. Arrows indicate filopodia. Bar represents 10 μm.
