FIGURE 9.

Schematic representation of the results. (A) Under normal Elongator complex activity, Acly’s enzymatic activity in the cytoplasm of neurons produces sufficient Ac-CoA for maintenance of acetylation levels of both Tau and MT via their respective acetyltransferases, contributing to normal neurite morphology. (B) Under Elongator complex deficiency (hElp1-KD), Acly’s enzymatic activity is compromised due to protein instability producing low Ac-CoA in the cytoplasm of neurons compromising acetylation levels required for maintenance of both Tau and MT causing polyubiquitylation and proteasomal degradation of Tau, contributing to MT instability and abnormal neurite morphology. Adapted from “Neuron Anatomy”, by BioRender.com (September 2020). Retrieved from https://app.biorender.com/biorender-templates/t-5f5b7e6139954000b2bde860-neuron-anatomy Copyright 2022 by BioRender.