Table 3. Neuroimaging characteristics of subjective cognitive decline subjects according to amyloid PET negativity or positivity on visual rating.
| Characteristics | Overall (n=120) | Amyloid PET (−) (n=94) | Amyloid PET (+) (n=26) | p-value |
|---|---|---|---|---|
| Frontal anterior lobe (%) | 3.8±0.2 | 3.8±0.3 | 3.8±0.2 | 0.678 |
| Frontal anterior medial lobe (%) | 5.8±0.3 | 5.8±0.3 | 5.8±0.3 | 0.348 |
| Frontal dorsolateral lobe (%) | 5.1±0.3 | 5.1±0.3 | 5.0±0.2 | 0.038 |
| Frontal inferior lobe (%) | 4.4±0.3 | 4.4±0.3 | 4.3±0.2 | 0.020 |
| Frontal posterior medial lobe (%) | 4.1±0.2 | 4.1±0.2 | 4.1±0.2 | 0.702 |
| Orbitofrontal lobe (%) | 2.4±0.2 | 2.4±0.2 | 2.4±0.2 | 0.745 |
| Temporal anterior lobe (%) | 2.3±0.2 | 2.3±0.2 | 2.2±0.2 | 0.010 |
| Temporal medial lobe (%) | 2.3±0.2 | 2.4±0.1 | 2.3±0.2 | 0.001 |
| Temporal lateral lobe (%) | 10.1±0.5 | 10.2±0.5 | 9.8±0.5 | 0.002 |
| Parietal lateral lobe (%) | 9.1±0.6 | 9.2±0.6 | 8.8±0.4 | 0.005 |
| Parietal medial lobe (%) | 5.1±0.3 | 5.1±0.3 | 5.1±0.3 | 0.487 |
| Occipital lobe (%) | 10.3±0.5 | 10.4±0.5 | 10.2±0.5 | 0.088 |
| Central lobe (%) | 9.2±0.5 | 9.3±0.5 | 8.9±0.4 | <0.001 |
| Cerebellum (%) | 11.2±0.8 | 11.3±0.8 | 11.1±0.7 | 0.268 |
| Ventricle (%) | 5.3±1.6 | 5.1±1.6 | 6.0±1.3 | 0.005 |
| Brain (%) | 85.3±3.3 | 85.8±3.3 | 83.8±2.7 | 0.004 |
| Total intracranial volume (cm3) | 1,353.6±122.2 | 1,345.4±120.7 | 1,382.5±125.3 | 0.178 |
| Lt. entorhinal cortex (%) | 0.0017±0.0002 | 0.0017±0.0002 | 0.0016±0.0002 | 0.009 |
| Rt. entorhinal cortex (%) | 0.0015±0.0002 | 0.0015±0.0002 | 0.0014±0.0002 | 0.028 |
| Lt. hippocampus (%) | 0.0024±0.0003 | 0.0024±0.0003 | 0.0023±0.0003 | 0.047 |
| Rt. hippocampus (%) | 0.0024±0.0002 | 0.0025±0.0002 | 0.0024±0.0002 | 0.061 |
Unless otherwise indicated, values are numbers (percentages) for categorical variables. The p-values were determined by the χ2 test, Fisher’s exact test, or the Wilcoxon rank sum test.
PET: positron emission tomography, Lt.: left, Rt.: right.