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. 2022 Oct 26;13:1025377. doi: 10.3389/fimmu.2022.1025377

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Copyright © 2022 Chunder, Schropp, Jabari, Marzin, Amor and Kuerten

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression profile of B cells after treatment with MMP-3. (A) Expression of B cell-related genes by pre-stimulated B cells treated with activated rMMP-3 relative to APMA in different donors (n = 6). B cells from 8 – 10 wells/condition/donor were pooled and measurements were done in duplicates. Values show the log₂fold change. (B) The graph represents the log₂fold change of significantly downregulated genes after MMP-3 treatment compared to the vehicle-treated group (p < 0.05) using paired t test.