TABLE 3.
Candidate genes tested for association with plasma MI concentration in young adults (Trinity Student Study)1
| Gene symbol | Protein | Function | SNPs, n | tagSNPs, n |
|---|---|---|---|---|
| Candidate genes tested for association with plasma MI | ||||
| SLC2A13 | Solute carrier family 2 member 13 | Inositol transport | 113 | 65 |
| SLC5A11 | Solute carrier family 5 member 11 | Inositol transport | 31 | 24 |
| SLC5A1 | Solute carrier family 5 member 13 | Glucose transport | 18 | 10 |
| SLC5A2 | Solute carrier family 5 member 13 | Glucose transport | 5 | 3 |
| SLC5A3 | Solute carrier family 5 member 13 | Glucose/inositol transport | 9 | 4 |
| Candidate genes relating to inositol synthesis and catabolism | ||||
| ISYNA1 | Inositol-3-phosphate synthase 1 | MI synthesis | 7 | 3 |
| IMPA1 | Inositol monophosphatase 1 | MI synthesis and IP recycling | 17 | 8 |
| MIOX | Myo-inositol oxygenase | MI catabolism | 13 | 13 |
| Candidate genes relating to production of highly phosphorylated inositol | ||||
| ITPK1 | Inositol-tetrakisphosphate 1-kinase | Inositol phosphate kinase | 48 | 36 |
| IMPK | Inositol polyphosphate multikinase | Inositol phosphate kinase | 17 | 8 |
1
Data for individual SNPs in candidate genes are provided in Supplemental Table 2. IP, inositol phosphate; MI, myo-inositol; SNP, single nucleotide polymorphism.