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. 2022 Oct 20;13:1002565. doi: 10.3389/fphar.2022.1002565

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Copyright © 2022 Ge, Li, Hu, Pu, Zhao and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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METTL3 is upregulated in esophageal squamous cell carcinoma (A,B). qPCR and WB were used to measure METTL3 expression in 4 pairs of ESCC tissues and corresponding adjacent tissues. (C). METTL3 expression levels in the TCGA database. (D). METTL3 was expressed in seven ESCC cell lines and HEEC cells. (E). Representative image of immunohistochemical staining by METTL3 in 100-fold (scaled bar = 100 μm) and 400-fold (scaled bar = 20 μm) magnified ESCC tissues and paired normal tissues in human samples (above). Immunohistochemical expression of METTL3 in ESCC tumor tissue and paired paracancerous tissues (PT) was quantitatively analyzed using ImageJ Profiler software (n = 7). n.s, no statistical significance, ***p < 0.001, ****p < 0.0001.