Table 3:

Regional analysis of neuropathology by autism-behavior status.

		Autism Unlikely	Autism Possible/ Very Likely	P Value
Region	Burden	Median (Q1–Q3)	Median (Q1 – Q3)	Loc. Scale
Frontal	Amyloid burden	95.58 (50.36 − 129.16)	94.88 (43.88 − 130.09)	0.93	0.69
	Amyloid density	72.84 (45.68 − 105.22)	85.48 (34.09 − 109.24)	0.60	0.77
	NFT density	3.24 (0.43 − 22.93)	21.79 (0.19 − 36.89)	0.58	0.028
	NP burden	13.39 (1.26 − 89.79)	84.06 (1.33 − 128.78)	0.55	0.17
	Tau burden	14.47 (2.50 − 89.79)	76.91 (2.73 − 137.54)	0.29	0.032
Occipital	Amyloid burden	30.95 (13.20 − 46.73)	44.06 (29.18 − 71.96)	0.04	0.74
	Amyloid density	37.09 (15.62 − 57.55)	50.45 (30.31 − 74.58)	0.09	0.66
	NFT density	1.57 (0.03 − 12.91)	2.65 (0.18 − 26.78)	0.35	0.65
	NP burden	8.20 (0.75 − 80.60)	18.95 (1.10 − 110.72)	0.62	0.35
	Tau burden	8.66 (1.30 − 67.22)	30.66 (1.91 − 115.83)	0.36	0.47
Parietal	Amyloid burden	82.05 (26.46 − 111.00)	75.55 (36.05 − 99.41)	0.74	0.13
	Amyloid density	67.66 (24.60 − 98.04)	56.83 (32.28 − 84.16)	0.93	0.042
	NFT density	5.40 (0.73 − 19.21)	14.42 (0.48 − 39.60)	0.22	0.46
	NP burden	23.81 (5.22 − 88.59)	61.06 (1.94 − 123.37)	0.35	0.20
	Tau burden	24.41 (5.59 − 92.73)	43.82 (3.38 − 144.73)	0.37	0.28
Temporal	Amyloid burden	70.31 (39.08 − 99.34)	78.19 (39.12 − 111.25)	0.68	0.51
	Amyloid density	51.65 (28.49 − 88.39)	61.59 (34.08 − 91.09)	0.65	0.51
	NFT density	15.14 (1.70 − 36.15)	32.09 (1.05 − 57.44)	0.30	0.048
	NP burden	78.69 (11.25 − 95.76)	91.06 (3.43 − 136.09)	0.60	0.042
	Tau burden	55.36 (10.23 − 96.61)	93.90 (5.56 − 137.75)	0.39	0.032

Values represent the pixel and lesion counts by pathologic type per region. P-values calculated by comparing the location (Loc.) using Wilcoxon statistic (as illustrated by the median) and scale by using the Ansari-Bradley statistic (as illustrated by the range from Q1 to Q3, the middle 50% of the measurements, where Q1 is the lower quartile while Q3 is the upper quartile). Red indicates statistical significance.