Fig. 5.

Model. 5hmC enrichment at exon 11 would favor its unproductive interaction with the Kdm6b promoter in ES cells. Productive contacts between CGI2 and CGI3 in a subset of cells would account for the basal Kdm6b expression detected at this stage. Upon differentiation, 5mC gain at exon 11 and TET3-mediated 5hmC gain at the CGI3 area would stabilize the CGI2–CGI3 productive interactions and ensure robust Kdm6b expression in NP cells