Table 2.
Targeted Capture Sequencing (CapIG-seq) identification of recurrent translocations in myeloma cell lines.
| Family/Gene | Translocation | Cell lines carrying translocation | Algorithm called | Manual review | Sensitivity |
|---|---|---|---|---|---|
| c-MAF | t(14;16) | ANBL6, ARD, ARP1, CAG, JJN3, KMS11, KMS26, MM1R, MM1S, OCI-MY5, PCM6 | 10/11 | 10/11 | 0.91 (0.74–1.08) |
| t(16;22) | XG6, Colo77, RPMI-8226 | 3/3 | 3/3 | 1.00 (1.00–1.00) | |
| MAFB | t(14;20) | ALMC1, ALMC2, EJM, SKMM1 | 3/4 | 3/4 | 0.75 (0.35–1.15) |
| t(8;20) | H929 | 1/1 | 1/1 | 1.00 (1.00–1.00) | |
| t(20;22) | L363 | 0/1 | 0/1 | 0.00 (0.00–0.00) | |
| FGFR/MMSET | t(4;14) | JIM1, JIM3, JMW1, KAS-6/1, KHM1, KMS11, KMS11adh, KMS11sus, KMS18, KMS26, KMS28BM, KMS28PE, KMS34, LP1, NCI-H929, OPM1, OPM2, PE2, UTMC2, XG7 | 18/20 | 20/20 | 1.00 (1.00–1.00) |
| CCND1 | t(11;14) | FLAM76, H1112, INA6, Karpas620, KMS12BM, KMS12PE, KMS21BM, KMS27, MOLP8, OCI-MY7, PE1, SKMM2, U266, XG1 | 7/14 | 10/14 | 0.71 (0.47–0.95) |
| CCND2 | t(12;14) | AMO1, XG2 | 1/2 | 1/2 | 0.50 (−0.19–1.19) |
| CCND3 | t(6;14) | SKMM1, FR4, KMM1 | 2/3 | 2/3 | 0.67 (0.14–1.2) |
| t(6;22) | OCI-MY1 | 1/1 | 1/1 | 1.00 (1.00–1.00) | |
| Novel translocations | |||||
| t(14;15) | KMS20 | Y | Y | ||
| t(14;17) | KMS21BM | Y | Y | ||
| t(14;18) | ARP, ARP1, CAG | Y | Y | ||
| *not c-MAF | t(14;16) | EJM | Y | Y | |
| *not-CCND1 | t(11;14) | L363 | Y | Y | |