Table 5.
Safety and treatment exposure according to age
| Parameter | < 70 years (n = 41) | ≥ 70 years (n = 10) |
|---|---|---|
| Any grade TEAE | 35 (85%) | 9 (90%) |
| Grade ≥ 3 TEAE | 14 (34%) | 5 (50%) |
| Dose interruptions * | ||
| Yes | 23 (56%) | 7 (78%) |
| No | 18 (44%) | 2 (22%) |
| Dose reduction * | ||
| Yes | 18 (44%) | 7 (78%) |
| No | 23 (56%) | 2 (22%) |
| Reason for discontinuation | ||
| Progression | 32 (78%) | 6 (60%) |
| Toxicity | 3 (7%) | 2 (20%) |
| Others† | 3 (7%) | 0 |
| On treatment | 3 (7%) | 2 (20%) |
Data are n (%). *1 patient aged > 70 years was excluded from the analysis as the recommended dose modification scheme was not followed. †Doctor’s or patient’s decision.