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. 2022 Nov 9;22:825. doi: 10.1186/s12879-022-07827-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Representative MRI findings in HIV-negative patients with CM. A 64-year-old man with HIV-negative CM. a–d DWI and ADC map showing multiple lacunar infarction in cerebellar vermis, bilateral cerebellar hemispheres and bilateral occipital lobe. e, f Gadolinium (Gd)-enhanced FLAIR showing meningeal enhancement of cerebral cortex and brain stem and cerebellum (posterior fossa exudates). g T2WI showing ventricular dilatation (hydrocephalus). h Another patient with HIV-negative CM. Gadolinium (Gd) contrast enhanced T1WI showing remarkable ring enhancement in the posterior inferior region of left splenium of corpus callosum (cryptococcoma). i–l The third patient with HIV-negative CM, DWI and ADC map showing multiple large infarctions at the left frontal, left temporal, bilateral occipital lobe