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. 2022 Nov 8;28:133. doi: 10.1186/s10020-022-00561-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — BMSC-exosomes downregulate microglial NOTCH2 expression. RT-qPCR (A) and western blots (B) were used to detect NOTCH2 expression in microglial cells after BMSC-exosome treatment; RT-qPCR (C), western blotting (D), and immunohistochemistry (E) were used to detect the expression of NOTCH2 in SDH; (F) Double immunofluorescence staining was used to localize NOTCH2. Data were shown as mean ± standard deviation. N = 6. ^*P < 0.05, vs. the sham group; ^#P < 0.05, vs. the SNL group. BMSC bone marrow mesenchymal stem cell, SDH spinal dorsal horn, SNL spinal nerve ligation