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. 2022 Nov 8;19:76. doi: 10.1186/s12986-022-00712-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Curcumin regulates genes involved in hepatic gluconeogenesis and de novo lipogenesis through gut microbiota. A Real-time quantitative PCR analysis of Pck1 and G6pc expression in the liver from HFD-fed mice treated with curcumin or vehicle for 4 weeks (n = 6/group). B Real-time quantitative PCR analysis of genes involved in DNL in the liver from mice in A (n = 6/group). C, D Real-time quantitative PCR analysis of Pck1 and G6pc expression (C) and genes involved in DNL (D) in the liver from vehicle- and curcumin-treated HFD-fed mice after antibiotic treatment (n = 6/group). E, F Real-time quantitative PCR analysis of Pck1 and G6pc expression (E) and genes involved in DNL (F) in the liver from endogenous gut microbiota-depleted mice colonized with the microbiota harvested from curcumin- and vehicle-treated HFD-fed mice (n = 6/group). Numerical data are shown as the mean ± SEM. *P < 0.05, **P < 0.01