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Upregulation of MINCR Prevents ECM-degeneration in ACLT rat model. (a)-(b) The mRNA and protein expression of SOX9, COL2A1, Aggrecan, ADAMTS-4, MMP3, and MMP13 were analyzed by qRT-PCR and western blot in the normal group, OA group, OA+OE-NC group, and OA+OE-MINCR group. (c)-(e) IF staining was utilized to detect the levels of ADAMTS-4, MMP13, COL2A1, and Aggrecan in the normal group, OA group, OA+OE-NC group, and OA+OE-MINCR group. *P < 0.05, **P < 0.01, ***P < 0.001.
