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. 2022 Nov 9;12:19089. doi: 10.1038/s41598-022-23342-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Receptor binding domain (RBD) contact surface observed in the angiotensin-converting enzyme 2 (ACE2) complex with the RBD (based on the crystal structure for the ACE2-RBD complex—PDB ID: 6M0J). Key RBD mutations that may impact ACE2 and/or antibody binding are color-coded by atom type (carbon—grey, nitrogen—blue, oxygen—red). (A) Alpha variant (B) Delta variant (C) Omicron variant.