Fig. 2. The way-finding game Sea Hero Quest is an example of a gamified smartphone tool that is sensitive to an increased genetic risk of AD (figure reprinted with permission from ref. [117]).

A Screenshot from the game. B The spatial trajectories of APOE-ε4 positive (red) vs. APOE-ε4 negative (green) participants on a selected Sea Hero Quest level. C The way-finding distance on the game differed significantly based on APOE-ε4 status.