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. 2022 Nov 9;12:19101. doi: 10.1038/s41598-022-21620-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative histologic and immunohistologic localisation of leukocytes responding to subunit vaccination and virus infection. (A) Mice were prime boost immunized i.p. or i.n. with L4R-b8r and αGC and lungs were harvested on d14 post boost. H&E staining of lungs from i.n. immunized mice showed prominent peri-vascular and peri-bronchiolar inflammatory infiltrate (lymphocytes and macrophages) compared to lungs of IP immunized mice. Data represent one of 3 lung sections per mouse from 3 mice per group. (B) Anti-CD3 staining of lung sections performed on d10—14 after booster immunization by i.p. or i.n. route as in Fig. 1. Arrows designate peri-vascular (PV), peri-bronchiolar (PB) and intravascular (IV) T cells. Scale bars, 50 μm. Data are representative of four sections per lung of two mice from two independent experiments per condition.