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. 2022 Nov 9;12:19101. doi: 10.1038/s41598-022-21620-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distinct transcriptome signatures define CD8⁺ lung IST Trm, MV Tem, and splenic Tm cells. (A) Principal component analysis of CD8⁺ IST Trm, MV Tem, and splenic Tm transcriptomes. (B–D) Volcano plots showing log₂ fold change against -log₁₀ adjusted p value of approximately 17,000 transcripts. Top 20 up and down regulated genes are shown in the volcano plots.