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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Drug Dev Res. 2019 Dec 4;81(3):338–349. doi: 10.1002/ddr.21625

FIGURE 2.

FIGURE 2

Reagents and conditions. (a) for 2a-g: EtOH, piperidine, NH2OH·HCl, 80°C, 2 hr; for 2h,i: MeOH/H2O (10:1), NH2OH·HCl, 100°C, 4 h; (b) m-CH3-Ph-COCl or cC3H5-COCl, dry THF, NaH (60% dispersion in mineral oil), r.t., 24 hr