Table 2.
Results of univariate logistic regression for the two selected endpoints: (a) the worsening of at least two functional scales (WS2) and (b) the worsening of at least three functional scales (WS3).
| Worsening of ≥2 functional scales (WS2) | Worsening of ≥3 functional scales (WS3) | |||
|---|---|---|---|---|
| Variables | p-value | Odds Ratio (95%CI) |
p-value | Odds Ratio (95%CI) |
| Age (years, continuous variable) |
0.29 | 0.98 (-0.03,+0.03) |
0.30 | 0.98 (-0.03,+0.03) |
| Body mass index (kg/m2,continuous variable) |
0.30 | 1.01 (-0.02,+0.02) |
0.20 | 1.01 (-0.02,+0.02) |
| Weight (kg, continuous variable) |
0.30 | 1.01 (-0.02,+0.02) |
0.27 | 1.01 (-0.02,+0.02) |
| Smoking history (current smoker vs. ex-smoker OR never smoker) |
0.18 | 1.49 (-0.66,+1.18) |
0.59 | 1.22 (-0.63,+1.30) |
| Alcohol (yes vs. no) |
0.55 | 1.14 (-0.41,+0.62) |
0.46 | 1.23 (-0.53,+0.92) |
| Use of alpha blockers (yes vs. no) |
0.86 | 0.96 (-0.38,+0.62) |
0.51 | 0.80 (-0.38,+0.74) |
| Use of antidepressant drugs (yes vs. no) |
0.87 | 0.93 (-0.51,+1.12) |
0.57 | 0.73 (-0.48,+1.39) |
| Use of beta blockers (yes vs. no) |
0.11* | 0.68 (-0.26,+0.41) |
0.30 | 0.73 (-0.33,+0.59) |
| Use of lipid-lowering drugs (yes vs. no) |
0.14* | 1.33 (-0.41,+0.60) |
0.52 | 1.16 (-0.43,+0.69) |
| Use of 5-alpha reductase inhibitors (yes vs. no) |
0.71 | 1.26 (-0.88,+2-96) |
0.37 | 1.83 (-1.34,+5.01) |
| Hypertension (yes vs. no) |
0.11* | 0.74 (-0.23,+0.33) |
0.14* | 0.71 (-0.26,+0.41) |
| Diabetes (yes vs. no) |
0.007* | 0.44 (-0.20,+0.36) |
0.02* | 0.36 (-0.21,+0.49) |
| History of heart disease (yes vs. no) |
0.46 | 0.85 (-0.39,+0.46) |
0.13* | 0.64 (-0.28,0.50) |
| Depression (yes vs. no) |
0.39 | 0.70 (-0.39,+0.86) |
0.44 | 0.66 (-0.43,+1.24) |
| Neo(adjuvant) hormone therapy (Yes/No) |
0.99 | 1.00 (-0.34,+0.52) |
0.73 | 0.91 (-0.39,+0.66) |
| Prescribed dose (EQD2Gy, alpha/beta=10 Gy, continuous variable) |
0.04* | 0.98 (-0.02,+0.02) |
0.34 | 0.99 (-0.02,+0.026) |
| Dose per fraction (Gy, continuous variable) |
0.002* | 1.80 (-0.55,+0.79) |
0.15 | 1.38 (-0.49,+0.76) |
| Planning target volume (cm3, continuous variable) |
0.28 | 1.00 (0,0) |
0.19 | 1.00 (0,0) |
| Treatment technique (IMRT/VMAT vs. 3DCRT) |
0.006* | 2.75 (-1.25,+2.31) |
0.0009* | 3.70 (-2.20,+5.59) |
| Weekly integral dose (L·Gy/week, continuous variable) |
0.0004* | 1.05 (-0.03,+0.03) |
0.002* | 1.05 (-0.03,+0.04) |
EQD2Gy, equivalent uniform dose at 2 Gy/fraction calculated using the linear quadratic model; 3DCRT, three- dimensional conformal radiation therapy; IMRT, intensity-modulated radiation therapy; VMAT, volumetric- modulated arc therapy.
P-values <0.05 are in italics; the p-values of the variables used in the multivariable logistic regression are followed with a star(*).