Fig. 3.

Re-docked conformer of P. falciparum FP-2 (3BPF); the figure indicates re-docking of the co-crystal ligand E64 into the predicted binding pocket of FP-2; predictable binding modes were observed experimentally in the active sites of FP-2 for all the test 1,2,4-trioxane derivatives; all the test compounds and redocked E64 are superimposed into the predicted binding sites of the original co-crystal structure (E64) in the FP-2 protein