Table 5B.
TOPKAT toxicity data of the designed 1,2,4-trioxane derivatives CC1–CC15
| Compounds code | Mouse female FDA | Mouse male FDA | Rat female FDA | Rat male FDA | Ames prediction |
|---|---|---|---|---|---|
| CC1 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC2 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC3 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC4 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC5 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC6 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC7 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC8 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC9 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC10 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC11 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC12 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | mutagen |
| CC13 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC14 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
| CC15 | non-carcinogen | non-carcinogen | non-carcinogen | non-carcinogen | non-mutagen |
FDA – food and drug administration; DTP – developmental toxicity potential