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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Annu Rev Cancer Biol. 2021 Dec 22;6(1):123–146. doi: 10.1146/annurev-cancerbio-070620-103554

Figure 3.

Figure 3

TGFβ is a master regulator of CD4+ T cell plasticity and function. Schematic of context-dependent TGFβ-mediated CD4+ T cell lineage choices that are determined by the presence of other cytokines in the milieu. Abbreviations: GARP, glycoprotein A repetitions predominant; LAP, latency-associated peptide; LTBP, latent TGFβ-binding protein; TCR, T cell receptor; Th, T helper; TME, tumor microenvironment; Treg, regulatory T cell.