Table 1. PfCRT haplotypes and PPQ and CQ phenotypes of lines used herein.

	PfCRT Haplotypes												pm2/3	pfmdr1	Phenotype
Parasite Line	74	75	76	97	145	220	271	326	343	353	356	371	Copies	Copies	PPQ	CQ
Dd2	I	E	T	H	F	S	E	S	M	G	T	I	1	2	S	R
Dd2Dd2crt	I	E	T	H	F	S	E	S	M	G	T	I	1	2	S	R
Dd2F145Icrt	I	E	T	H	I	S	E	S	M	G	T	I	1	2	Rhigh	S
Dd2M343Lcrt	I	E	T	H	F	S	E	S	L	G	T	I	1	2	Rlow	S
Dd2G353Vcrt	I	E	T	H	F	S	E	S	M	V	T	I	1	2	Rmod	S
Dd23D7crt	M	N	K	H	F	A	Q	N	M	G	I	R	1	2	S	S
RF7	I	E	T	H	F	S	E	S	L	G	T	I	3	1	Rhigh	R
RF12	I	E	T	Y	F	S	E	S	M	G	T	I	2	1	Rhigh	R

All parasite lines were cloned prior to use (Dd2-B2 was used for Dd2). RF7 and RF12 carry the K13 C580Y mutation that confers in vitro resistance to artemisinin derivatives. CQ, chloroquine; mod, moderate; pm2/3, plasmepsins 2 and 3; pfmdr1, P. falciparum multidrug resistance protein 1; PPQ, piperaquine.