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Role of CD47/SIRPα. On the one hand, after binding to CD47, ITIM in the cytoplasmic tail of SIRPα on macrophage activates inhibitory tyrosine phosphatases SHP-1 and SHP-2, resulting in inhibition of the actin cytoskeleton rearrangement required for phagocytosis. On the other hand, SIRPα on DC inhibits the antigen presentation of tumor cells. ITIM, tyrosine-based inhibitory motif; DC, dendritic cell.
