Figure 4.

Role of SLAM family. In T cells, the activation of self-ligand SLAMF7 immune receptor could induce phosphorylation of STAT1 and STAT3 and expression of various inhibitory receptors and transcription factors associated with T cell exhaustion. In macrophages, SLAMF7 could mediate phagocytosis interacting with integrin Mac-1 and do with signals involving immune-receptor tyrosine-based activation motifs. While most SLAM-mediated phagocytosis functions depend on SAP adaptors. SLAMF3 and SLAMF4 are identified as “don’t eat me” receptors on macrophages which inhibit “eat-me” signals such as LRP1-mediated activation of mTOR and Syk through SH2 domain-containing phosphatases. STAT, signal transduction and activator of transcription; SAP, signaling lymphocyte activation molecule-associated protein; GPI, glycosyl phosphatidyl inositol.