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Role of PD-1/PD-L1. PD-1-expressing macrophages exhibit an anti- inflammatory-like surface profile in tumor settings. PD-1 expression is negatively correlated to phagocytic ability of macrophages. PD-L1 antibody treatment promotes cell proliferation of cultured bone marrow-derived macrophages, which is related to the activation of the AKT-mTOR pathway. PD-1, programmed cell death 1; PD-L1, programmed cell death ligand 1.
