Table 2. Joinpoint analysis for ASIR, ASMR and ASR of DALY rate of colorectal cancer by sex in China and the U.S. between 1990 and 2019.

Measure	Location	Sex	Trend 1			Trend 2			Trend 3			Trend 4			Trend 5			Trend 6		1990−2019 AAPC (95% CI)
			Years	APC		Years	APC		Years	APC		Years	APC		Years	APC		Years	APC
ASIR, age-standardized incidence rate; ASMR, age-standardized mortality rate; DALY, disability-adjusted life-year; ASR, age-standardized rate; APC, annual percentage change; AAPC, average annual percentage change; 95% CI, 95% confidence interval; NA, not applicable; *, significantly different from zero, P<0.05.
ASIR	China	Both	1990−1996	0.79*		1996−2000	3.55*		2000−2004	7.53*		2004−2011	4.18*		2011−2016	0.30		2016−2019	3.69*	3.11* (2.89, 3.33)
		Female	1990−1996	0.40*		1996−2000	2.45*		2000−2004	5.37*		2004−2010	3.21*		2010−2016	−0.12		2016−2019	3.65*	2.16* (1.94, 2.38)
		Male	1990−1996	1.08*		1996−2000	4.46*		2000−2004	8.80*		2004−2011	5.08*		2011−2016	0.88*		2016−2019	3.45*	3.75* (3.48, 4.03)
	the U.S.	Both	1990−1994	1.06*		1994−2002	−0.38*		2002−2006	−2.85*		2006−2019	−0.24*		NA	NA		NA	NA	−0.47* (−0.71, −0.22)
		Female	1990−1994	0.94*		1994−2002	−0.15		2002−2006	−2.75*		2006−2019	−0.42*		NA	NA		NA	NA	−0.49* (−0.71, −0.27)
		Male	1990−1994	1.08*		1994−2002	−0.74*		2002−2006	−2.88*		2006−2015	−0.38*		2015−2019	0.65		NA	NA	−0.48* (−0.76, −0.21)
ASMR	China	Both	1990−1996	−0.11		1996−1999	1.36		1999−2004	4.41*		2004−2011	1.13*		2011−2016	−1.37*		NA	NA	1.05* (0.83, 1.27)
		Female	1990−1998	−0.51*		1998−2004	2.55*		2004−2011	−0.01*		2011−2015	−2.51*		2015−2019	0.97*		NA	NA	0.16* (0.03, 0.29)
		Male	1990−1995	0.02		1995−1999	1.93*		1999−2004	5.53*		2004−2011	2.10*		2011−2017	−0.59*		2017−2019	1.84	1.71* (1.45, 1.98)
	the U.S.	Both	1990−2002	−1.04*		2002−2006	−2.80*		2006−2014	−1.08*		2014−2019	0.35		NA	NA		NA	NA	−1.06* (−1.23, −0.89)
		Female	1990−2001	−0.89*		2001−2007	−2.24*		2007−2013	−1.23*		2013−2019	−0.17		NA	NA		NA	NA	−1.09* (−1.24, −0.94)
		Male	1990−1995	−0.73*		1995−1998	−2.09*		1998−2002	−1.05*		2002−2006	−3.06*		2006−2014	−1.09*		2014−2019	0.65*	−1.10* (−1.33, −0.87)
ASR of DALY	China	Both	1990−1996	−0.48*		1996−1999	1.14		1999−2004	4.31*		2004−2011	0.94*		2011−2016	−1.32*		2016−2019	1.56*	0.91* (0.72, 1.09)
		Female	1990−1997	−0.71*		1997−2001	1.07*		2001−2004	2.04*		2004−2011	−0.39*		2011−2015	−2.40*		2015−2019	0.92*	−0.12 (−0.27, 0.03)
		Male	1990−1996	−0.25		1996−1999	1.93*		1999−2004	5.99*		2004−2011	1.83*		2011−2016	−0.84*		2016−2019	1.41*	1.60* (1.36, 1.84)
	the U.S.	Both	1990−1995	−0.60*		1995−1998	−1.85*		1998−2001	−0.30		2001−2006	−2.33*		2006−2013	−0.85*		2013−2019	0.24	−0.88* (-1.13, −0.64)
		Female	1990−2002	−0.95*		2002−2006	−2.35*		2006−2012	−1.17*		2012−2019	−0.03		NA	NA		NA	NA	−0.97* (−1.13, −0.81)
		Male	1990−1995	−0.52*		1995−1998	−2.18*		1998−2002	−0.84*		2002−2006	−2.71*		2006−2014	−0.65*		2014−2019	0.53*	−0.90* (−1.14, −0.66)