Table S1. Changes in No. of cases of colorectal cancer from 1990 to 2019 apportioned into changes due to demographics and risk.

Metric	Country	Sex	No. of cases	Changes due to demographics (%)	Changes due to risk (%)	Net change (%)
DALY, disability-adjusted life-year. Baseline group: No. of cases in 1990; Compared group: No. of cases in 2019. Demographic effects include aging and the size of the population.
Incidence	China	Both	502,044	229.75	245.27	475.02
		Female	168,680	198.04	146.61	344.65
		Male	333,364	254.42	333.06	587.48
	the U.S.	Both	74,083	66.24	−17.86	48.38
		Female	28,876	55.64	−17.51	38.13
		Male	45,206	79.88	−21.46	58.42
Death	China	Both	182,531	169.25	61.22	230.47
		Female	59,786	151.61	8.93	160.54
		Male	122,745	184.44	108.10	292.54
	the U.S.	Both	18,449	62.79	−34.65	28.14
		Female	6,629	52.56	−32.81	19.75
		Male	11,820	77.32	−40.38	36.94
DALY	China	Both	4,129,668	135.11	47.50	182.61
		Female	1,195,913	119.52	−3.27	116.25
		Male	2,933,756	146.84	91.15	237.99
	the U.S.	Both	390,973	60.54	−31.98	28.56
		Female	124,992	123.27	−104.17	19.09
		Male	265,981	117.11	−79.87	37.24