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. 2022 Oct 27;13:968165. doi: 10.3389/fimmu.2022.968165

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Copyright © 2022 Khan, Lin, Wang, Chen, Huang, Tian, Yuan and Bu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular subtypes based on the necroptosis-related genes expression. (A) Consensus clustering matrix (k=2) identified two clusters (C1 = 248; C2 = 123) based on the expression of the 55 NRGs. (B) The clusters demonstrated significant difference in overall survival (p<0.007). (C) Heatmap illustrating association between the clusters and their clinicopathological features of the gastric cancer patients (TNM staging. T: primary tumor; N: lymph node; M: metastasis. Degree of differentiation. G1: highly differentiated; G2: moderately differentiated; G3: poorly differentiated). P value are shown as *P < 0.05; **P < 0.01. (D) Distribution of NRGs expression between the clusters (P values are shown as: *P < 0.05; **P < 0.01; ***P < 0.001).