Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 27;13:968165. doi: 10.3389/fimmu.2022.968165

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Khan, Lin, Wang, Chen, Huang, Tian, Yuan and Bu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Construction of competing endogenous RNA (ceRNA) network of NRGPI genes. (A) Scrutiny of miRNA by (I) obtaining miRNA targets from miRWalk version 3.0 (n = 2158); (II) screening for miRNA expression in TCGA STAD cohort (n = 1798); (III) followed by gene-miRNA target correlation analysis (n = 122); and (IV) survival significance (n = 72). (B) lncRNA targets (n = 16877) were obtained for the 72 miRNA targets (I), which were then (II) screened for individual target-based correlation analysis (positive correlation with risk gene and negative correlation with miRNA). (C) A mRNA-miRNA-lncRNA (ceRNA) network (9 risk genes-21 miRNAs-32 lncRNAs) was constructed. Kaplan-Meier curves of survival analysis for miRNA targets of NRGPI oncogene (D-G) and NRGPI tumor suppressor genes (H–K). Correlation was tested with Spearman’s correlation test with the following criteria: R=0.2 and p value <0.001.