Suppression of PBMC proliferation to TT by STF and whole-cell killed bacteria. Whole-cell S. typhi, S. aureus, S. flexneri, and highly purified STF (4 μg/ml) were incubated with or without TT (2 μg/ml), and the ability to stimulate T-cell proliferation was determined. Shown are the results from an individual representative of two vaccinated volunteers evaluated in two independent experiments with similar results. The P values are as compared to cells treated with TT alone. SD, standard deviation.