FIG. 9.

Effects of neutralization of IL-1β, TNF-α, IL-6, or IL-10 on STF-induced suppression of the proliferation induced by TT. PBMC from a vaccinated individual were incubated with TT (2 μg/ml), STF (4 μg/ml), or a combination of TT and STF in the absence or presence of an optimal concentration (1 μg/ml) of neutralizing monoclonal antibodies to IL-1β, TNF-α, IL-6, or IL-10, and T-cell proliferation was determined. Similar results were obtained with PBMC from an additional vaccinated volunteer. mIg, normal mouse Ig. SD, standard deviation.