Table 1.

Summary on PoD values of genotoxic endpoints of ENU

Tests	Target endpoint	Timepoint	PoD (mg/kg bw/d)
			NOGEL	BMDL0.05CESa	BMDL0.1CES	BMDL0.5CES	BMDLCES1SD
Pig−a gene mutation assay	Blood RBC	14	0.5	0.003	0.011	0.17	0.094
		28	0.25	0.0094	0.021	0.12	0.19
	Blood RET	14	0.5	NT	NT	NTb	0.87
		28	0.5	NT	NT	0.0036	0.66
Micronucleus assay	Blood RET	4	4	NT	NTc	0.15	NT
		14	1	NT	NT	0.13	NT
		28	1	NT	NT	0.16	NT
	Bone marrow RET	29	0.5	0.01	0.032	0.45	0.14
Comet assay	Blood cell	4	0.5	0.11	0.18	0.55	0.34
		14	0.25	0.038	0.087	0.56	0.85
		28	0.25	0.004	0.018	0.34	0.32
	Liver cell	29	0.25	0.17	0.25	0.62	0.52

Abbreviations: PoD points of departure, RBC red blood cell, RET reticulocytes, NOGEL no observed genotoxic effect level, BMDL the lower bound of benchmark dose, CES critical effect sizes

^aRaw data was used for BMDL fitting. CES set at 0.05, 0.1, 0.5, and 1SD. NT: Averaging model failed to fit (P < 0.1)

^bBMDU/BMDL = 223

^cBMDU/BMDL = 259 × 10²