Table 2.
Summary on PoD values of genotoxic endpoints of EMS
| Tests | Target endpoint | Timepoint | PoD (mg/kg bw/d) | ||||
|---|---|---|---|---|---|---|---|
| NOGEL | BMDL0.05CESa | BMDL0.1CESb | BMDL0.5CESc | BMDLCES1SDd | |||
| Pig-a gene mutation assay | Blood RBC | 14 | 40 | NT | NT | NTb | 2.1 |
| 28 | 20 | 1.1 | 2.3 | 12 | 14 | ||
| Blood RET | 14 | 160 | NTc | NTd | 1.7 | 53 | |
| 28 | 80 | NTe | 0.3 | 4.7 | 110 | ||
| Micronucleus assay | Blood RET | 4 | 80 | 3.8 | 12 | 52 | 25 |
| 14 | 80 | 19 | 27 | 63 | 43 | ||
| 28 | 40 | 1.1 | 2.6 | 16 | 7.9 | ||
| Bone marrow RET | 29 | 20 | 0.99 | 2.6 | 15 | 5.8 | |
| Comet assay | Blood cell | 4 | 20 | 0.86 | 1.9 | 11 | 22 |
| 28 | 20 | 1 | 2.1 | 13 | 23 | ||
| Liver cell | 29 | 20 | 6.2 | 8.9 | 22 | 28 | |
Abbreviations: PoD points of departure, RBC red blood cell, RET reticulocytes, NOGEL no observed genotoxic effect level, BMDL the lower bound of benchmark dose, CES. critical effect sizes
a Raw data was used for BMDL fitting. CES set at 0.05, 0.1, 0.5, and 1SD. NT: Averaging model failed to fit (P. <0.1)
b.BMDU / BMDL =12×102
c. BMDU / BMDL =893
d. BMDU / BMDL =347
e. BMDU / BMDL =424