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. 2022 Nov 9;13(11):942. doi: 10.1038/s41419-022-05393-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The subcellular localization of HOXA11-AS was verified by RT-qPCR (A) and FISH (B) experiments in U87 and LN229 cell lines. C The binding mode of HOXA11-AS to Ago2 protein was predicted via molecular docking analysis. D The binding of HOXA11-AS to Ago2 protein was verified by RIP experiment. E The ceRNA network diagram was constructed by mRNA and small RNA sequencing after HOXA11-AS overexpression in U87 cell line. F The expression of let-7b-5p, miR-504-5p, and miR-1180-3p in U87 and LN229 cells infected with Lv-HOXA11-AS were quantified by RT-qPCR. G The combination of HOXA11-AS and let-7b-5p was verified by ChIRP assay. H Luciferase reporter assay in U87 and LN229 cells co-transfected with let-7b-5p mimics, pSICHECK2-wild type HOXA11-AS (WT) or pSICHECK2-mutant type HOXA11-AS (Mut) plasmids. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.