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. 2022 Nov 9;13:6772. doi: 10.1038/s41467-022-34408-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A, B Co-occurrence analysis for B-cell MC groups. Probabilistic model-based co-occurrence analysis was performed using malignant B-cells only from 154 FL samples without additional adjustment for multiple testing (see Methods section). A Co-occurrence matrix. Blue and yellow shaded boxes indicate statistically significant positive and negative co-occurrences, respectively (p < 0.05; probabilistic model-based co-occurrence test, 2-sided). B Co-occurrence network diagram. Force-directed graphing of co-occurrence associations. Each node represents a B-cell MC group. Edges indicate statistically significant positive or negative co-occurrence associations (p < 0.05; probabilistic model-based co-occurrence test, 2-sided). Lengths of edges and positioning of nodes are determined by a combination of attractive and repulsive forces which in sum are proportional to the strength of pairwise associations. C Intratumoral entropy score distribution among all FL samples (n = 154). Tumors with low entropy score contain cells mapping to a single PG, while tumors with high entropy scores contain cells mapping to up to 8 different PGs. D Composition of FL samples according to B-cell PG clusters. Bubbles within each row (= sample) indicate cells assigned to a given PG cluster (=column) with size proportional to their relative abundance in the sample (each row adding up to 100%). Bubbles are colored by PG cluster. PG clusters are grouped into metacluster (MC) groups. Samples are grouped by presence of MC-A and/or MC-B cells. FL follicular lymphoma, PG Phenograph, MC metacluster.