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. 2022 Nov 9;12:19037. doi: 10.1038/s41598-022-23006-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of silymarin standard and brequinar combination: (A) dose-effect curve and its linearization (B) median-effect plot for each single drug and combination treatment (C) combination index plot and (D) dose-normalized isobologram for various effects (10%, 30%, 50%, 70 and 90%) in the combinations of silymarin standard and brequinar.