Table 5.
Fractional inhibition of hDHODH, combination index values (CI) and DRI values of Allium sativum extract and brequinar in combination at several effect levels.
| (Fa × 100) % (hDHODH) Inhibition of the combined drugs (%) |
CI values |
Dose (ug/ml) Allium sativum extract |
Dose (nM) Brequinar |
DRI Allium sativum extract |
DRI Brequinar |
|---|---|---|---|---|---|
| 11 |
1.84 (Ant) |
39.32 | 2.05 | 1.09 | 1.09 |
| 39 |
1.46 (Ant) |
142.08 | 6.96 | 1.38 | 1.35 |
| 72 |
0.95 (Syn) |
431.44 | 19.99 | 2.14 | 2.05 |
| 78 |
1.46 (Ant) |
545.62 | 24.99 | 1.38 | 1.36 |
| 98 |
0.47 (Syn) |
5062.94 | 207.41 | 4.38 | 4.08 |
Fa signifies fraction affected. CI < 1, = 1, and > 1 indicate synergism (Syn), additive effect (Add), and antagonism (Ant), respectively. DRI > 1 indicates favourable dose reduction (in fold) for the drug in combination.