Table 7.
Fractional inhibition of hDHODH, combination index values (CI) and DRI values of silymarin standard extract and brequinar in combination at several effect levels.
| (Fa × 100) % (hDHODH) Inhibition of the combined drugs (%) |
CI values |
Dose (ug/ml) Silymarin standard extract | Dose (nM) Brequinar |
DRI Silymarin standard extract |
DRI Brequinar |
|---|---|---|---|---|---|
| 17 |
1.33 (Ant) |
47.76 | 2.92 | 1.46 | 1.55 |
| 33 |
1.79 (Ant) |
85.75 | 5.81 | 1.10 | 1.13 |
| 72 |
1.03 (Add) |
245.88 | 19.99 | 1.84 | 2.05 |
| 83 |
1.14 (Ant) |
373.37 | 32.64 | 1.63 | 1.77 |
| 98 |
0.55 (Syn) |
1805.11 | 207.41 | 3.32 | 4.08 |
Fa signifies fraction affected. CI < 1, = 1, and > 1 indicate synergism (Syn), additive effect (Add), and antagonism (Ant), respectively. DRI > 1 indicates favourable dose reduction (in fold) for the drug in combination.