TABLE 1.
ENC50 of antiendotoxin agents determined by the Limulus ELISA
| Agent | ENC50 (mean ± SD) against endotoxina
|
||||
|---|---|---|---|---|---|
| Lipid A | E. coli LPS | S. abortus equi LPS | P. aeruginosa LPS | N. meningitidis LPS | |
| LF-33 | 0.10 ± 0.017 μM | 0.52 ± 0.078 μM | 0.39 ± 0.054 μM | 2.08 ± 0.37 μM | 3.08 ± 0.44 μM |
| LF-27 | 0.63 ± 0.093 μM | 7.45 ± 1.12 μM | >300 μM | >300 μM | >300 μM |
| Polymyxin B | 0.19 ± 0.021 μM | 1.95 ± 0.26 μM | 18.2 ± 2.85 μM | 3.91 ± 0.73 μM | >100 μM |
| Human serum | >50% | 0.03% ± 0.005% | 2.1% ± 0.29% | 0.63% ± 0.11% | 2.52% ± 0.41% |
a
The ENC50 against 200 EU of endotoxin per ml was measured.