Table 1.
Cytotoxic activity of tetrahydroquinoline derivatives against various cancer and normal cells presented as an IC50value referring to the concentration that inhibits 50% of cell growth.
| Compound | Cell lines | |||||
|---|---|---|---|---|---|---|
| HCT-116 | A549 | MCF-7 | HepG2 | Hela | HEK293 | |
| IC50 (µM) | ||||||
| 5 | 13.10 ± 0.96 | > 50 | > 50 | > 50 | > 50 | > 50 |
| 4a | 12.18 ± 1.61**** | 11.33 ± 0.67**** | > 50 | > 50 | > 50 | 49.01 ± 2.21 |
| 6 | 15.61 ± 1.29 | 40.18 ± 0.94 | > 50 | > 50 | 50 | > 50 |
| 4b | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
| 4c | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
| 4d | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
| 4e | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
| 5-FU | 5.78 ± 0.38**** | 8.12 ± 1.01*** | 8.41 ± 0.98** | 13.12 ± 0.32* | 11.09 ± 1.53* | 16.82 ± 0.34 |
| ETP | 0.39 ± 0.01ns | 0.54 ± 0.21ns | 0.83 ± 0.15ns | 5.01 ± 0.22ns | 3.40 ± 0.51ns | 1.91 ± 0.97 |
Data are expressed as the mean ± SD (µM) of n = 3 independent experiments. ****p < 0.00001 in comparison to IC50 for HEK293 (Student’s t-test).