Table 1.

Top SNPs from genome-wide significant loci.

				GWAS1	GWAS2	CE	Italy	Spain	Sweden	UK	Meta-analysis
SNP	Chromosome	risk/other allele	Info Score1	RR (95% CI)	RR (95% CI)	RR (95% CI)	RR (95% CI)	RR 95% CI	RR 95% CI	RR 95% CI	RR 95% CI	p value	Corrected p value2
rs1924557	1:82047934	T/C	0.93	1.75 (0.68−4.47)	3.61 (1.37−9.49)	3.76 (2.16−6.53)	2.03 (0.98−4.19)	3.51 (1.33−9.26)	1.23 (0.68−2.22)	5.00 (1.59−15.7)	2.35 (1.82−3.03)	6.65 × 10−11	2.67 × 10−10
rs4745	1:155106227	T/A	0.96	1.19 (0.72−1.98)	1.40 (0.91−2.16)	1.47 (1.16−1.87)	1.80 (1.16−2.78)	1.17 (0.73−1.86)	1.63 (1.13−2.36)	1.16 (0.77−1.74)	1.50 (1.32−1.71)	4.44 × 10−10	1.58 × 10−9
rs80215221	3:137550420	G/A	0.99	2.29 (1.29−4.09)	1.95 (1.20−3.17)	1.39 (1.08−1.79)	1.89 (1.24−2.89)	2.82(1.76−4.52)	1.70 (1.16−2.51)	1.99 (1.31−3.03)	1.68 (1.47−1.92)	2.26 × 10−14	1.49 × 10−13
rs6874700	5:50701750	A/T	0.99	2.54 (1.49−4.33)	1.33 (0.87−2.02)	1.60 (1.28−2.01)	1.98 (1.33−2.95)	2.14 (1.33−3.45)	1.94 (1.32−2.83)	1.84 (1.20−2.80)	1.91 (1.68−2.16)	5.58 × 10−24	1.48 × 10−22
11:119964758:G:C	11:119964758	G/C	0.98	1.38 (0.81−2.36)	1.54 (0.98−2.42)	1.32 (1.03−1.69)	1.35 (0.90−2.04)	1.14(0.72−1.80)	1.68 (1.12−2.52)	2.13 (1.40−3.24)	1.47 (1.29−1.68)	8.89 × 10−9	2.63 × 10−8
rs10862001	12:80002106	A/G	0.83	2.02 (1.12−3.64)	1.48 (0.89−2.47)	1.77 (1.27−2.45)	1.97 (1.22−3.18)	1.03 (0.55−1.93)	2.11 (1.26−3.54)	0.83 (0.40−1.69)	1.68 (1.43−1.99)	6.84 × 10−10	2.37 × 10−9
rs10853087	17:45006112	C/G	0.97	1.18 (0.72−1.93)	1.44 (0.94−2.21)	1.63 (1.29−2.06)	1.60 (1.08−2.38)	1.46 (0.93−2.29)	1.26 (0.87−1.83)	1.53 (1.01−2.31)	1.47 (1.30−1.66)	1.41 × 10−9	4.67 × 10−9
20:55165923:G:A	20:55165923	G/A	0.97	2.30 (1.13−4.67)	1.72 (0.95−3.12)	1.46 (1.08−1.98)	2.57 (1.39−4.76)	1.00 (0.58−1.71)	2.08 (1.23−3.51)	1.89 (1.04−3.43)	1.65 (1.39−1.96)	7.31 × 10−9	2.19 × 10−8

¹Mean imputation quality score (Info score)). Chromosomal positions are annotated according to Human Genome version 19 (hg19); CE Central Europe, UK United Kingdom

²p value corrected for genomic inflation λ = 1.068