Table 3.

RNA expression patterns of coding and non-coding genes in the LD blocks of the most significant GWAS markers in mouse and human embryonic urogenital tissue.

Mouse embryonic transcriptome data					Human embryonic transcriptome data
Marker	Gene	log2fc E10.5 vs. E12.5	log2fc E10.5 vs. 15.5	log2fc E12.5 vs. 15.5	Gene	log2fc 7 vs. 7-7.5	log2fc 7-7.5 vs. 7.5	log2fc 7 vs. 7.5	log2fc 7.5 vs. 8	log2fc 7 vs. 9	log2fc 8 vs. 9
rs1924557	LPHN2	−0.21	0.57	−1.16	LPHN2	0.16	−0.54	−0.38	0.09	−0.10	0.19
rs4745	EFNA1	−0.12	−0.76	−0.64	EFNA1	−0.25	−0.34	−0.58	0.00	−0.30	0.28
rs4745	SLC50A1	0.80	1.34	0.54	SLC50A1	0.03	0.07	0.10	−0.28	−0.18	0.00
rs4745	DPM3	0.06	0.86	0.81	DPM3	0.00	−1.72	−1.72	0.19	−0.52	1.00
rs4745	KRTCAP2	0.27	0.31	−0.04	KRTCAP2	−0.58	0.00	−0.58	0.58	−0.58	0.58
rs6874700	ISL1	−0.26	−5.01	−4.76	ISL1	−1.26	0.88	−0.38	−1.37	−1.48	0.28
11:119964758	TRIM29	1.90	1.10	−0.80	TRIM29	2.00	−1.26	0.74	0.00	1.87	1.14
rs10862001	SYT1	2.85	2.41	−0.44	SYT1	−0.25	1.04	0.79	−2.54	0.08	1.8
rs10862001	PAWR	−0.32	1.37	1.69	PAWR	0.70	0.55	1.25	−1.66	0.32	0.74
rs10853087	GOSR2	−0.16	−0.44	−0.28	GOSR2	−0.14	0.34	0.19	−0.19	−0.14	−0.14

Marker	Non-coding Gene	log2fc E10.5 vs. E12.5	log2fc E10.5 vs. 15.5	log2fc E12.5 vs. 15.5	Non-coding gene	log2fc 7 vs. 7–7.5	log2fc 7–7.5 vs. 7.5	log2fc 7 vs. 7.5	log2fc 7.5 vs. 8	log2fc 7 vs. 9	log2fc 8 vs. 9
rs6874700	HMGB1P47	n.e.			HMGB1P47	−2.00	0.00	−2.00	activated	−3.00	suppressed
rs6874700	ISL1−DT	n.e.			ISL1−DT	−1.38	0.85	−0.53	−1.8	−1.61	0.00
rs10853087	LINC01974	n.e.			LINC01974			n.e.
20:55165923	LINC01716	n.e.			LINC01716			n.e.

Bold: differential expressed genes (log2fc <−1.5 or >1.5).

log2fc log2 fold change, vs. versus, Chr. chromosome, n.e. not expressed. Differential expression defined with log2fc <−1,5 or >1,5.