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. 2022 Nov 9;8:452. doi: 10.1038/s41420-022-01235-7

Table 2.

Paracrine effectors of MSCs in the regulation of macrophage polarization.

Factors Effectiveness Mechanisms Reference
TSG6 Induce M2 macrophages polarization Suppress NF-κB pathway activation [42]
TSG6 Inhibit macrophages migration Bind to CD44 [55]
PGE2 Convert macrophages into regenerative phenotype Not mentioned [56]
IL-33 Enhance M2 macrophages polarization Not mentioned [57]
miR-182 Convert M1 macrophages to M2 phenotype Inhibit TLR4 expression [45]