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. 2022 Oct 27;13:1003376. doi: 10.3389/fimmu.2022.1003376

Figure 1.

Figure 1

Factors that play a role in process of liver regeneration. IL-6 and TNF-α induce the priming phase. Complete mitogens including HGF, EGF, HB-EGF and TGF-α, together with auxiliary mitogens BAs, norepinephrine, TNF, IL-6, vascular endothelial growth factor, insulin-like growth factor system, estrogen, serotonin, leptin, complement, FGF1 and FGF2 involve in the proliferation phase. And the termination phase is induced by TGF-β. NE, norepinephrine, VEGF, vascular endothelial growth factor, IGF, insulin-like growth factor.